Standard Article

Complement

Immunology

Innate Immunity and Infection

  1. B. Paul Morgan FRCPath MRCP PhD

Published Online: 15 MAR 2010

DOI: 10.1002/9780470688618.taw0090

Topley and Wilson's Microbiology and Microbial Infections

Topley and Wilson's Microbiology and Microbial Infections

How to Cite

Morgan, B. P. 2010. Complement. Topley and Wilson's Microbiology and Microbial Infections. .

Author Information

  1. University of Wales College of Medicine, Department of Medical Biochemistry and Immunology, Cardiff, UK

Publication History

  1. Published Online: 15 MAR 2010

Abstract

  • 1
    Introduction
  • 2
    Historical Aspects
  • 3
    The Anatomy of the C System
  • 4
    Regulation of C
  • 5
    Complement Deficiencies
  • 6
    Complement in Specific Pathologies
  • 7
    Complement Therapies
  • 8
    Concluding Remarks

Keywords:

  • complement (C), component of innate immunity and pathogen defense;
  • C system component proteins;
  • constituent pathways of C system and component proteins in sequential order;
  • classical pathway activation;
  • alternative pathway activation efficiency and low-level or ‘tickover’ activation;
  • membrane attack pathway;
  • role of C in apoptosis;
  • complement therapies, manipulating C system therapeutically in diseases