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Lymphocyte-Mediated Cytotoxicity

Immunology

Acquired Immunity

  1. Eckhard R. Podack Professor and Chairman

Published Online: 15 MAR 2010

DOI: 10.1002/9780470688618.taw0106

Topley and Wilson's Microbiology and Microbial Infections

Topley and Wilson's Microbiology and Microbial Infections

How to Cite

Podack, E. R. 2010. Lymphocyte-Mediated Cytotoxicity. Topley and Wilson's Microbiology and Microbial Infections. .

Author Information

  1. University of Miami School of Medicine, Department of Microbiology and Immunology, Miami, FL, USA

Publication History

  1. Published Online: 15 MAR 2010

Abstract

  • 1
    Cytotoxic Lymphocytes
  • 2
    CTLs and NK Cell Morphology and Function
  • 3
    Killing
  • 4
    Composition of Cytolytic Granules of CTLs and NK Cells
  • 5
    Killer Cell Self-Protection
  • 6
    Target Cell Death
  • 7
    Role of Perforin in the Induction of CTL Activation
  • 8
    Perforin Function in Homeostasis
  • 9
    Homeostatic Function of Fas and Fas-L
  • 10
    Genetic Defects of Cytotoxicity
  • 11
    Perforin Deficiency and Defects in Cytotoxicity in Humans
  • 12
    Granzyme Deficiencies
  • 13
    DPP1 Deficiency (Cathepsin C)
  • 14
    Cytotoxicity and Anti-Tumor Defense

Keywords:

  • lymphocyte-mediated cytotoxicity;
  • cytotoxic lymphocytes;
  • CTLs and NK cell morphology and function;
  • composition of cytolytic granules of CTLs and NK cells;
  • killer cell self-protection;
  • target cell death and cytotoxicity genetic defects;
  • perforin function in homeostasis;
  • cytotoxicity and anti-tumor defense