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Naked DNA Vaccines

Immunology

Vaccines

  1. Linda S. Klavinskis BSc PhD Senior Lecturer

Published Online: 15 MAR 2010

DOI: 10.1002/9780470688618.taw0125

Topley and Wilson's Microbiology and Microbial Infections

Topley and Wilson's Microbiology and Microbial Infections

How to Cite

Klavinskis, L. S. 2010. Naked DNA Vaccines. Topley and Wilson's Microbiology and Microbial Infections. .

Author Information

  1. Guys Hospital, Peter Gorer Department of Immunobiology, Guys, Kings’ and St. Thomas’ School of Medicine, London, UK

Publication History

  1. Published Online: 15 MAR 2010

Abstract

  • 1
    Historical Background
  • 2
    Description of DNA Expression Vectors
  • 3
    Routes and Mode of DNA Vaccine Delivery
  • 4
    Generation of Immune Responses by Naked DNA Vaccines
  • 5
    Augmenting the Immunogenicity of DNA Vaccines
  • 6
    Safety Considerations for Vaccine Administration in Humans
  • 7
    Clinical Trials
  • 8
    Conclusions
  • 9
    Acknowledgments

Keywords:

  • naked DNA vaccines;
  • DNA expression vectors;
  • DNA vaccine delivery-routes and mode;
  • immune response generation by naked DNA vaccines;
  • DNA vaccines containing human cytomegalovirus (CMV) immediate/early (IE) promoter;
  • CpG motifs of plasmid DNA;
  • augmenting DNA vaccine immunogenicity;
  • codon optimization usage for eukaryotic cells-enhancing antigen expression