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Human Immunodeficiency Virus

Virology

Specific Viruses and Viral Infections

  1. Ulrich Schubert PhD1,
  2. Myra McClure PhD DSc FRCPath Professor of Retrovirolgy and, Honorary Consultant in GU Medicine, Head of Section of Infectious Diseases2

Published Online: 15 MAR 2010

DOI: 10.1002/9780470688618.taw0266

Topley and Wilson's Microbiology and Microbial Infections

Topley and Wilson's Microbiology and Microbial Infections

How to Cite

Schubert, U. and McClure, M. 2010. Human Immunodeficiency Virus. Topley and Wilson's Microbiology and Microbial Infections. .

Author Information

  1. 1

    University of Erlangen-Nürnberg, Institute for Clinical and Molecular Virology, Erlangen, Germany

  2. 2

    Wright-Fleming Institute, Jefferiss Research Trust Laboratories, Faculty of Medicine, Imperial College London, London, UK

Publication History

  1. Published Online: 15 MAR 2010

Abstract

  • 1
    Introduction
  • 2
    Genomic Organization and Replication Cycle of HIV
  • 3
    Role of Cellular Factors in HIV Replication
  • 4
    Molecular Structure and Function of HIV Regulator Proteins
  • 5
    The Lentivirus Protein R (Vpr)
  • 6
    Structure and Function of the HIV-1 Specific Vpu Protein
  • 7
    The Viral Infectivity Factor Vif
  • 8
    The Multifunctional Nef Protein
  • 9
    Dynamics of Viral Replication
  • 10
    Enzyme Infidelity and Genetic Variation
  • 11
    HIV-1 Subtypes
  • 12
    The Clinical Impact of Viral Diversity
  • 13
    Subtype Variability and the Prospect of a Vaccine
  • 14
    HIV Therapy and the Emergence of Resistance
  • 15
    Mechanisms of Drug Resistance
  • 16
    Acknowledgments

Keywords:

  • human immunodeficiency virus;
  • reverse transcriptase (RT);
  • protease (PR);
  • ubiquitin proteasome system (UPS);
  • cyclophilin A (CypA);
  • cyclosporin A (CsA);
  • ubiquitin E2 variant (UEV);
  • lentivirus protein R (VPR)