Chapter 4. Induction of Cytochrome P450 Systems

  1. Michael D. Coleman DSc.

Published Online: 12 APR 2010

DOI: 10.1002/9780470689332.ch4

Human Drug Metabolism: An Introduction, Second Edition

Human Drug Metabolism: An Introduction, Second Edition

How to Cite

Coleman, M. D. (2010) Induction of Cytochrome P450 Systems, in Human Drug Metabolism: An Introduction, Second Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470689332.ch4

Author Information

  1. Aston University, Birmingham, UK

Publication History

  1. Published Online: 12 APR 2010
  2. Published Print: 9 APR 2010

ISBN Information

Print ISBN: 9780470742174

Online ISBN: 9780470689332

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Keywords:

  • cytochrome P450 Systems induction;
  • accelerated clearance Causes - drug metabolism inducers;
  • enzyme induction - enzyme inducers features;
  • hepatic metabolism inducers types;
  • enzyme induction mechanisms - inducible CYPs;
  • enzyme induction - general clinical aspects and timescale;
  • epilepsy and brain tumors - gilomas - malignant brain gial cells;
  • Anti-epileptic drugs (AEDs) - anticonvulsants;
  • inducible CYPs - AEDs - accelerated anticancer drug clearence;
  • anticoagulant drugs - warfarin and valve replacement

Summary

This chapter contains sections titled:

  • Introduction

  • Causes of accelerated clearance

  • Enzyme induction

  • Mechanisms of enzyme induction

  • Induction – general clinical aspects