Chapter 10. Epilepsy

  1. Michael R. Trimble MD, FRCP, FRCPsych Professor of Behavioural Neurology1 and
  2. Mark S. George MD Distinguished Professor of Psychiatry Director MUSC Director2,3,4,5,6

Published Online: 21 JUL 2010

DOI: 10.1002/9780470689394.ch10

Biological Psychiatry, Third Edition

Biological Psychiatry, Third Edition

How to Cite

Trimble, M. R. and George, M. S. (2010) Epilepsy, in Biological Psychiatry, Third Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470689394.ch10

Author Information

  1. 1

    Institute of Neurology, Queen Square, London UK

  2. 2

    Radiology and Neurosciences, Medical University of South Carolina, USA

  3. 3

    Brain Stimulation Laboratory, Medical University of South Carolina, USA

  4. 4

    Center for Advanced Imaging Research (CAIR), Medical University of South Carolina, USA

  5. 5

    SC Brain Imaging Center of Excellence, Medical University of South Carolina, USA

  6. 6

    Ralph H. Johnson VA Medical Center, Charleston, SC, USA

Publication History

  1. Published Online: 21 JUL 2010
  2. Published Print: 27 AUG 2010

ISBN Information

Print ISBN: 9780470688946

Online ISBN: 9780470689394



  • epilepsy;
  • drugs and stimulation devices in epilepsy management - treating psychopathology;
  • classification of epilepsies;
  • prognosis of epilepsy, dependent on aetiology - age of onset of condition;
  • electrical status epilepticus of slow-wave sleep, ESES;
  • division of epilepsy - idiopathic and symptomatic groups in patients with no known or suspected aetiology, than potential hereditary disposition;
  • early-childhood epilepsy - likely to be idiopathic;
  • symptomatic epilepsy;
  • ictally-related psychiatric disorders;
  • interictal dysphoric disorder (IDD)


This chapter contains sections titled:

  • Introduction

  • Prevalence and clinical characteristics

  • Classification

  • Genetics

  • Symptomatic epilepsy

  • Biochemical findings

  • Investigation and differential diagnosis

  • Psychiatric disorders in epilepsy

  • Cognitive deterioration and epilepsy

  • Some outstanding issues