Chapter 11. The Dementias

  1. Michael R. Trimble MD, FRCP, FRCPsych Professor of Behavioural Neurology1 and
  2. Mark S. George MD Distinguished Professor of Psychiatry Director MUSC Director2,3,4,5,6

Published Online: 21 JUL 2010

DOI: 10.1002/9780470689394.ch11

Biological Psychiatry, Third Edition

Biological Psychiatry, Third Edition

How to Cite

Trimble, M. R. and George, M. S. (2010) The Dementias, in Biological Psychiatry, Third Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470689394.ch11

Author Information

  1. 1

    Institute of Neurology, Queen Square, London UK

  2. 2

    Radiology and Neurosciences, Medical University of South Carolina, USA

  3. 3

    Brain Stimulation Laboratory, Medical University of South Carolina, USA

  4. 4

    Center for Advanced Imaging Research (CAIR), Medical University of South Carolina, USA

  5. 5

    SC Brain Imaging Center of Excellence, Medical University of South Carolina, USA

  6. 6

    Ralph H. Johnson VA Medical Center, Charleston, SC, USA

Publication History

  1. Published Online: 21 JUL 2010
  2. Published Print: 27 AUG 2010

ISBN Information

Print ISBN: 9780470688946

Online ISBN: 9780470689394



  • dementias;
  • understanding of neuropathological and neurochemical bases of dementias;
  • ICD 10, dementia as a syndrome - disease of brain, of chronic or progressive nature;
  • dementia, posing one of the most rapidly increasing medical problems - in the Western world;
  • affective symptoms, present - with lability of affect, tearfulness, withdrawal and frank depressive symptoms;
  • dementia of the Alzheimer type (DAT);
  • anomia, commonest impairment - following comprehension difficulties;
  • tauopathies;
  • dementia with Lewy bodies - syndrome of dementia with extrapyramidal rigidity;
  • HIV encephalopathy - as AIDS–dementia complex, caused by virus HTLV-111


This chapter contains sections titled:

  • Introduction

  • Definition

  • Prevalence

  • Diagnosis and classification

  • Alzheimer's disease

  • Dementia of frontal-lobe type

  • Focal cortical atrophies

  • Dementia with Lewy bodies

  • Vascular dementias

  • Other forms of dementia

  • Further causes of dementia

  • Some outstanding issues