Chapter 12. Biological Treatments

  1. Michael R. Trimble MD, FRCP, FRCPsych Professor of Behavioural Neurology1 and
  2. Mark S. George MD Distinguished Professor of Psychiatry Director MUSC Director2,3,4,5,6

Published Online: 21 JUL 2010

DOI: 10.1002/9780470689394.ch12

Biological Psychiatry, Third Edition

Biological Psychiatry, Third Edition

How to Cite

Trimble, M. R. and George, M. S. (2010) Biological Treatments, in Biological Psychiatry, Third Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470689394.ch12

Author Information

  1. 1

    Institute of Neurology, Queen Square, London UK

  2. 2

    Radiology and Neurosciences, Medical University of South Carolina, USA

  3. 3

    Brain Stimulation Laboratory, Medical University of South Carolina, USA

  4. 4

    Center for Advanced Imaging Research (CAIR), Medical University of South Carolina, USA

  5. 5

    SC Brain Imaging Center of Excellence, Medical University of South Carolina, USA

  6. 6

    Ralph H. Johnson VA Medical Center, Charleston, SC, USA

Publication History

  1. Published Online: 21 JUL 2010
  2. Published Print: 27 AUG 2010

ISBN Information

Print ISBN: 9780470688946

Online ISBN: 9780470689394



  • biological treatments;
  • old and new brain-stimulation techniques - electroconvulsive therapy (ECT), vagus-nerve stimulation (VNS), DBS and TMS;
  • distribution, determined by relative blood flow of organs - and blood–brain barrier presence;
  • mode of action of tricyclic drugs - to their ability to inhibit;
  • CRF system, longstanding focus of interest;
  • side effects of non-MAOI antidepressant drugs;
  • ‘antipsychotic’ group of drugs - important action, to lyse psychotic symptoms;
  • D1 and D2 receptor-site antagonism;
  • anxiolytics and hypnotics - three main groups, barbiturates, benzodiazepines and others;
  • beta-adrenergic blockers, as propranolol - in cardiovascular disorder management


This chapter contains sections titled:

  • Introduction

  • Pharmacology: pharmacokinetics and pharmacodynamics

  • Antidepressants

  • Antipsychotic drugs

  • Anxiolytics and hypnotics

  • Beta-Adrenergic blockers

  • Lithium

  • Anticonvulsants

  • Drugs for the treatment of dementia

  • Medications for the addictions

  • Brain-stimulation therapies

  • Sleep-deprivation therapy