Chapter 3. Important Brain–Behaviour Relationships

  1. Michael R. Trimble MD, FRCP, FRCPsych Professor of Behavioural Neurology1 and
  2. Mark S. George MD Distinguished Professor of Psychiatry Director MUSC Director2,3,4,5,6

Published Online: 21 JUL 2010

DOI: 10.1002/9780470689394.ch3

Biological Psychiatry, Third Edition

Biological Psychiatry, Third Edition

How to Cite

Trimble, M. R. and George, M. S. (2010) Important Brain–Behaviour Relationships, in Biological Psychiatry, Third Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470689394.ch3

Author Information

  1. 1

    Institute of Neurology, Queen Square, London UK

  2. 2

    Radiology and Neurosciences, Medical University of South Carolina, USA

  3. 3

    Brain Stimulation Laboratory, Medical University of South Carolina, USA

  4. 4

    Center for Advanced Imaging Research (CAIR), Medical University of South Carolina, USA

  5. 5

    SC Brain Imaging Center of Excellence, Medical University of South Carolina, USA

  6. 6

    Ralph H. Johnson VA Medical Center, Charleston, SC, USA

Publication History

  1. Published Online: 21 JUL 2010
  2. Published Print: 27 AUG 2010

ISBN Information

Print ISBN: 9780470688946

Online ISBN: 9780470689394



  • important brain–behaviour relationships;
  • limbic system in MacLean's scheme - three key mammalian behaviours, nursing and maternal care and audiovocal communications;
  • Paul MacLean's concept of limbic system - involving the ‘triune brain’;
  • hypothalamus role - in regulating eating and drinking;
  • CCK findings and CCK antagonists with anxiolytic properties;
  • cingulate epilepsy, characterized by brief episodes of alteration of consciousness;
  • hippocampus, major cortical connections with entorhinal cortex;
  • parahippocampal gyrus and entorhinal cortex;
  • area of basal ganglia circuitry - targets for DBS;
  • limbic lobe disorders in clinical context


This chapter contains sections titled:

  • Introduction

  • Important anatomical structures for understanding behaviour

  • Some specific behaviours

  • Limbic lobe disorders in a clinical context

  • Re-entrant circuits in a clinical context

  • The frontal lobes in a clinical context

  • Laterality