Chapter 5. Personality Disorders

  1. Michael R. Trimble MD, FRCP, FRCPsych Professor of Behavioural Neurology1 and
  2. Mark S. George MD Distinguished Professor of Psychiatry Director MUSC Director2,3,4,5,6

Published Online: 21 JUL 2010

DOI: 10.1002/9780470689394.ch5

Biological Psychiatry, Third Edition

Biological Psychiatry, Third Edition

How to Cite

Trimble, M. R. and George, M. S. (2010) Personality Disorders, in Biological Psychiatry, Third Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470689394.ch5

Author Information

  1. 1

    Institute of Neurology, Queen Square, London UK

  2. 2

    Radiology and Neurosciences, Medical University of South Carolina, USA

  3. 3

    Brain Stimulation Laboratory, Medical University of South Carolina, USA

  4. 4

    Center for Advanced Imaging Research (CAIR), Medical University of South Carolina, USA

  5. 5

    SC Brain Imaging Center of Excellence, Medical University of South Carolina, USA

  6. 6

    Ralph H. Johnson VA Medical Center, Charleston, SC, USA

Publication History

  1. Published Online: 21 JUL 2010
  2. Published Print: 27 AUG 2010

ISBN Information

Print ISBN: 9780470688946

Online ISBN: 9780470689394



  • personality disorders;
  • psychopathic personality, terms used by Schneider - in embracing differing abnormal personality patterns;
  • anxious personality (ICD 10) - those who display lifelong anxiety;
  • links between personality and psychiatric illness;
  • genetics of specific personality disorders;
  • new genetic studies - associations between specific gene alleles and temperament;
  • platelet MAO activity;
  • link between hostility, aggression and low 5-HT concentrations;
  • neurophysiological and neurological data;
  • frontal–subcortical axis, not only central to behavioural disorders - but determining personality propensities


This chapter contains sections titled:

  • General introduction

  • Introduction to the concept of personality

  • Genetics

  • Somatic variables

  • Metabolic and biochemical findings

  • Neurophysiological and neurological data

  • Some outstanding issues