Chapter 6. Anxiety Disorders

  1. Michael R. Trimble MD, FRCP, FRCPsych Professor of Behavioural Neurology1 and
  2. Mark S. George MD Distinguished Professor of Psychiatry Director MUSC Director2,3,4,5,6

Published Online: 21 JUL 2010

DOI: 10.1002/9780470689394.ch6

Biological Psychiatry, Third Edition

Biological Psychiatry, Third Edition

How to Cite

Trimble, M. R. and George, M. S. (2010) Anxiety Disorders, in Biological Psychiatry, Third Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470689394.ch6

Author Information

  1. 1

    Institute of Neurology, Queen Square, London UK

  2. 2

    Radiology and Neurosciences, Medical University of South Carolina, USA

  3. 3

    Brain Stimulation Laboratory, Medical University of South Carolina, USA

  4. 4

    Center for Advanced Imaging Research (CAIR), Medical University of South Carolina, USA

  5. 5

    SC Brain Imaging Center of Excellence, Medical University of South Carolina, USA

  6. 6

    Ralph H. Johnson VA Medical Center, Charleston, SC, USA

Publication History

  1. Published Online: 21 JUL 2010
  2. Published Print: 27 AUG 2010

ISBN Information

Print ISBN: 9780470688946

Online ISBN: 9780470689394



  • anxiety disorders;
  • anxiety disorders, predominant symptom - anxiety not associated with another psychiatric disorder;
  • obsessive–compulsive disorder (OCD) - reactions to severe stress and adjustment disorders;
  • social phobia, fear of embarrassment or humiliation in social situations;
  • phobic disorders, reflecting persistent and irrational fears - resulting in avoidance behaviour;
  • phobic-anxiety depersonalization syndrome;
  • psychophysical variables - and generalized anxiety investigated;
  • neurochemical investigation - anxiety with abnormal adrenergic or 5 H-T activity and link with benzodiazepine receptors;
  • PET studies of lactate-induced panic disorder - right parahippocampal and bitemporal activation;
  • post-traumatic stress disorder


This chapter contains sections titled:

  • Introduction

  • Genetics

  • Somatic variables

  • Metabolic and biochemical findings

  • Neurochemical investigations

  • Neurophysiological and neurological data

  • Imaging

  • Obsessive–compulsive disorder

  • Post-traumatic stress disorder

  • Some outstanding issues