Chapter 7. The Schizophrenias

  1. Michael R. Trimble MD, FRCP, FRCPsych Professor of Behavioural Neurology1 and
  2. Mark S. George MD Distinguished Professor of Psychiatry Director MUSC Director2,3,4,5,6

Published Online: 21 JUL 2010

DOI: 10.1002/9780470689394.ch7

Biological Psychiatry, Third Edition

Biological Psychiatry, Third Edition

How to Cite

Trimble, M. R. and George, M. S. (2010) The Schizophrenias, in Biological Psychiatry, Third Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470689394.ch7

Author Information

  1. 1

    Institute of Neurology, Queen Square, London UK

  2. 2

    Radiology and Neurosciences, Medical University of South Carolina, USA

  3. 3

    Brain Stimulation Laboratory, Medical University of South Carolina, USA

  4. 4

    Center for Advanced Imaging Research (CAIR), Medical University of South Carolina, USA

  5. 5

    SC Brain Imaging Center of Excellence, Medical University of South Carolina, USA

  6. 6

    Ralph H. Johnson VA Medical Center, Charleston, SC, USA

Publication History

  1. Published Online: 21 JUL 2010
  2. Published Print: 27 AUG 2010

ISBN Information

Print ISBN: 9780470688946

Online ISBN: 9780470689394



  • schizophrenias;
  • schizophrenia, a single disease entity - causing confusion in psychiatry;
  • International Pilot Study of Schizophrenia;
  • DSM IV-TR, characteristic symptoms - as hallucinations, delusions and thought disorder;
  • DSM IV-TR, psychotic disorder - due to general medical conditions;
  • NAPLS (the North America Prodrome Longitudinal Study);
  • platelet MAO activity in schizophrenia;
  • dopamine hypothesis;
  • noradrenergic hypothesis;
  • PET findings in syndromes of schizophrenia


This chapter contains sections titled:

  • Introduction

  • Genetics

  • Somatic variables

  • Metabolic and biochemical findings

  • Neurochemical investigations

  • Neurophysiological and neurological data

  • Some outstanding issues