Chapter 8. Affective Disorders

  1. Michael R. Trimble MD, FRCP, FRCPsych Professor of Behavioural Neurology1 and
  2. Mark S. George MD Distinguished Professor of Psychiatry Director MUSC Director2,3,4,5,6

Published Online: 21 JUL 2010

DOI: 10.1002/9780470689394.ch8

Biological Psychiatry, Third Edition

Biological Psychiatry, Third Edition

How to Cite

Trimble, M. R. and George, M. S. (2010) Affective Disorders, in Biological Psychiatry, Third Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470689394.ch8

Author Information

  1. 1

    Institute of Neurology, Queen Square, London UK

  2. 2

    Radiology and Neurosciences, Medical University of South Carolina, USA

  3. 3

    Brain Stimulation Laboratory, Medical University of South Carolina, USA

  4. 4

    Center for Advanced Imaging Research (CAIR), Medical University of South Carolina, USA

  5. 5

    SC Brain Imaging Center of Excellence, Medical University of South Carolina, USA

  6. 6

    Ralph H. Johnson VA Medical Center, Charleston, SC, USA

Publication History

  1. Published Online: 21 JUL 2010
  2. Published Print: 27 AUG 2010

ISBN Information

Print ISBN: 9780470688946

Online ISBN: 9780470689394



  • affective disorders;
  • recurring theme, confusion between depression as illness - and reaction or an ordinary state of misery or grief;
  • disturbance of mood - continuing to be embodied in DSM IV-TR;
  • familial pure depression disease (FPDD);
  • linkage studies of bipolar disorder - to date, not revealing reliable markers;
  • tryptophan hydrolase gene, significant association between genotype and low CSF 5-HIAA levels;
  • 5-HT (Serotonin) hypothesis;
  • BDNF, compound of interest recently;
  • new form of functional brain imaging - involving examining a ‘resting state’;
  • neuropsychological disturbances in affective disorder


This chapter contains sections titled:

  • Introduction

  • Genetics

  • Metabolic and biochemical findings

  • Neurochemical investigations

  • Neurophysiological and neurological data

  • Some outstanding issues