Chapter 9. The Addictions and Disorders of Motivation

  1. Michael R. Trimble MD, FRCP, FRCPsych Professor of Behavioural Neurology1 and
  2. Mark S. George MD Distinguished Professor of Psychiatry Director MUSC Director2,3,4,5,6

Published Online: 21 JUL 2010

DOI: 10.1002/9780470689394.ch9

Biological Psychiatry, Third Edition

Biological Psychiatry, Third Edition

How to Cite

Trimble, M. R. and George, M. S. (2010) The Addictions and Disorders of Motivation, in Biological Psychiatry, Third Edition, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470689394.ch9

Author Information

  1. 1

    Institute of Neurology, Queen Square, London UK

  2. 2

    Radiology and Neurosciences, Medical University of South Carolina, USA

  3. 3

    Brain Stimulation Laboratory, Medical University of South Carolina, USA

  4. 4

    Center for Advanced Imaging Research (CAIR), Medical University of South Carolina, USA

  5. 5

    SC Brain Imaging Center of Excellence, Medical University of South Carolina, USA

  6. 6

    Ralph H. Johnson VA Medical Center, Charleston, SC, USA

Publication History

  1. Published Online: 21 JUL 2010
  2. Published Print: 27 AUG 2010

ISBN Information

Print ISBN: 9780470688946

Online ISBN: 9780470689394



  • addictions and disorders of motivation;
  • National Institute on Drug Abuse (NIDA);
  • US National Epidemiologic Survey on Alcohol and Related Conditions (NESARC);
  • addiction, not only a brain-based disorder - central to understanding of wider spectrum of conditions, ‘disorders of motivation’;
  • genetics of alcoholism;
  • pathways and sites of action of substance-abuse drugs - on cerebral structures;
  • imaging studies of addictive temperament or disordered motivation;
  • associations with neurological disease;
  • neuropsychiatric disorders and alteration of motivation;
  • role of glutamate receptors, dopamine importance - and links between episodic and emotional cues to learning and memory


This chapter contains sections titled:

  • Introduction

  • Disorders of motivation

  • Conditioning

  • Genetics

  • Metabolic and biochemical findings

  • Neurophysiological and neurological data

  • Some outstanding issues