Chapter 20. Tolerance in Heart Transplantation: Current and Future Role

  1. Ronald Ross Watson1,2 and
  2. Douglas F. Larson3
  1. Kimberly Gandy,
  2. Jos Domen and
  3. Jack Copeland

Published Online: 15 APR 2008

DOI: 10.1002/9780470692325.ch20

Immune Dysfunction and Immunotherapy in Heart Disease

Immune Dysfunction and Immunotherapy in Heart Disease

How to Cite

Gandy, K., Domen, J. and Copeland, J. (2007) Tolerance in Heart Transplantation: Current and Future Role, in Immune Dysfunction and Immunotherapy in Heart Disease (eds R. R. Watson and D. F. Larson), Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470692325.ch20

Editor Information

  1. 1

    Department of Nutritional Sciences, The University of Arizona; and Sarver Heart Center, College of Medicine, The University of Arizona

  2. 2

    Division of Health Promotion Sciences, Mel and Enid Zuckerman Arizona College of Public Health, The University of Arizona Tucson, AZ USA

  3. 3

    Sarver Heart Center College of Medicine The University of Arizona Tucson, AZ USA

Publication History

  1. Published Online: 15 APR 2008
  2. Published Print: 30 AUG 2007

ISBN Information

Print ISBN: 9781405155687

Online ISBN: 9780470692325

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Keywords:

  • heart transplantation;
  • immune system;
  • hypertension;
  • peripheral tolerance;
  • regulatory cells

Summary

This chapter contains section titled:

  • Introduction

  • Need for tolerance

  • Definition of tolerance

  • Mechanisms of tolerance induction

  • Central tolerance

  • Peripheral tolerance

  • Regulatory cells

  • Re-programming

  • Peripheral deletion

  • Cytokine milieu

  • Clinical protocols

  • Withdrawal of immunosuppression after conventional protocols

  • Tolerance through pharmacology

  • Costimulatory blockade

  • Peripheral T-cell depletion

  • Tolerance through cellular therapy

  • Total lymphoid irradiation

  • Mixed chimerism

  • Hematopoietic reconstitution

  • Incomplete tolerance

  • Myocardial rescue

  • Summary

  • References