Chapter 23. Cholesterol, Interleukin‒6 Inflammation, and Atherosclerosis—Role of Statins, Bisphosphonates, and Plant Polyphenols in Atherosclerosis and Other Diseases of Aging

  1. Ronald Ross Watson1,2 and
  2. Douglas F. Larson3
  1. Sota Omoigui

Published Online: 15 APR 2008

DOI: 10.1002/9780470692325.ch23

Immune Dysfunction and Immunotherapy in Heart Disease

Immune Dysfunction and Immunotherapy in Heart Disease

How to Cite

Omoigui, S. (2007) Cholesterol, Interleukin‒6 Inflammation, and Atherosclerosis—Role of Statins, Bisphosphonates, and Plant Polyphenols in Atherosclerosis and Other Diseases of Aging, in Immune Dysfunction and Immunotherapy in Heart Disease (eds R. R. Watson and D. F. Larson), Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470692325.ch23

Editor Information

  1. 1

    Department of Nutritional Sciences, The University of Arizona; and Sarver Heart Center, College of Medicine, The University of Arizona

  2. 2

    Division of Health Promotion Sciences, Mel and Enid Zuckerman Arizona College of Public Health, The University of Arizona Tucson, AZ USA

  3. 3

    Sarver Heart Center College of Medicine The University of Arizona Tucson, AZ USA

Publication History

  1. Published Online: 15 APR 2008
  2. Published Print: 30 AUG 2007

ISBN Information

Print ISBN: 9781405155687

Online ISBN: 9780470692325

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Keywords:

  • hippocrates;
  • atherosclerosis;
  • fibrous elements;
  • metabolism;
  • pathogeneis

Summary

This chapter contains section titled:

  • Introduction

  • Atherosclerosis

  • Acute phase response

  • Cholesterol metabolism

  • Interleukin-6

  • Protein kinases

  • Tyrosine kinase

  • Serine/threonine kinases

  • Dimeric transcription factors

  • Nuclear factor-κB

  • Peroxisome proliferator-activated receptors

  • Activation of IL-6 inflammation by isoprenoids

  • Inhibition of cholesterol pathway by statins

  • Inhibition of cholesterol pathway by bisphosphonates

  • Plant products-fungi, polyphenolic compounds, and fatty acids

  • Atherosclerosis and IL-6

  • Statins and IL-6

  • Bisphosphonates and IL-6

  • Plant polyphenols, fatty acids, and IL-6

  • Atherosclerosis and statins

  • Atherosclerosis and bisphosphonates

  • Atherosclerosis, plant polyphenols, and fatty acids

  • Type 2 diabetes and IL-6

  • Type 2 diabetes and bisphosphonates

  • Type 2 diabetes and statins

  • Type 2 diabetes, plant polyphenols, and fatty acids

  • Osteoporosis and IL-6

  • Osteoporosis and bisphosphonates

  • Osteoporosis and statins

  • Osteoporosis, plant polyphenols, and fatty acids

  • Aging, age-related disorders, and IL-6

  • Aging, age-related disorders, IL-6, and gene therapy/modulation

  • Conclusion

  • References