Chapter 15. Statistical Methods for Examining Heterogeneity and Combining Results from Several Studies in Meta-Analysis

  1. Matthias Egger1,
  2. George Davey Smith2 and
  3. Douglas G Altman3
  1. Jonathan J Deeks,
  2. Douglas G Altman and
  3. Michael J Bradburn

Published Online: 17 MAR 2008

DOI: 10.1002/9780470693926.ch15

Systematic Reviews in Health Care: Meta-Analysis in Context, Second Edition

Systematic Reviews in Health Care: Meta-Analysis in Context, Second Edition

How to Cite

Deeks, J. J., Altman, D. G. and Bradburn, M. J. (2001) Statistical Methods for Examining Heterogeneity and Combining Results from Several Studies in Meta-Analysis, in Systematic Reviews in Health Care: Meta-Analysis in Context, Second Edition (eds M. Egger, G. D. Smith and D. G. Altman), BMJ Publishing Group, London, UK. doi: 10.1002/9780470693926.ch15

Editor Information

  1. 1

    Senior Lecturer in Epidemiology and Public Health Medicine, Division of Health Services, Research and MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, UK

  2. 2

    Professor of Clinical Epidemiology, Division of Epidemiology and MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, UK

  3. 3

    Professor of Statistics in Medicine, ICRF Medical Statistics, Group, Centre for Statistics in Medicine, Institute of Health Sciences, University of Oxford, UK

Publication History

  1. Published Online: 17 MAR 2008
  2. Published Print: 1 JAN 2001

ISBN Information

Print ISBN: 9780727914880

Online ISBN: 9780470693926

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Keywords:

  • statistical methods;
  • heterogeneity;
  • meta-analysis;
  • hazard ratios;
  • computational methods

Summary

This chapter contains section titled:

  • Summary Points

  • Meta—Analysis

  • Formulae for Estimates of Effect from Individual Studies

  • Formulae for Deriving a Summary (Pooled) Estimate of the Treatment Effect by Combining Trial Results (Meta—Analysis)

  • Use of Stratified Analyses for Investigating Sources of Heterogeneity

  • Meta—Analysis with Individual Patient Data

  • Additional Analyses

  • Some Practical Issues

  • Other Methods of Meta—Analysis

  • Discussion

  • Acknowledgements