Chapter 9. Why and how Sources of Heterogeneity Should be Investigated

  1. Matthias Egger1,
  2. George Davey Smith2 and
  3. Douglas G Altman3
  1. Simon G Thompson

Published Online: 17 MAR 2008

DOI: 10.1002/9780470693926.ch9

Systematic Reviews in Health Care: Meta-Analysis in Context, Second Edition

Systematic Reviews in Health Care: Meta-Analysis in Context, Second Edition

How to Cite

Thompson, S. G. (2001) Why and how Sources of Heterogeneity Should be Investigated, in Systematic Reviews in Health Care: Meta-Analysis in Context, Second Edition (eds M. Egger, G. D. Smith and D. G. Altman), BMJ Publishing Group, London, UK. doi: 10.1002/9780470693926.ch9

Editor Information

  1. 1

    Senior Lecturer in Epidemiology and Public Health Medicine, Division of Health Services, Research and MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, UK

  2. 2

    Professor of Clinical Epidemiology, Division of Epidemiology and MRC Health Services Research Collaboration, Department of Social Medicine, University of Bristol, UK

  3. 3

    Professor of Statistics in Medicine, ICRF Medical Statistics, Group, Centre for Statistics in Medicine, Institute of Health Sciences, University of Oxford, UK

Publication History

  1. Published Online: 17 MAR 2008
  2. Published Print: 1 JAN 2001

ISBN Information

Print ISBN: 9780727914880

Online ISBN: 9780470693926

SEARCH

Keywords:

  • heterogeneity;
  • meta-analysis;
  • statistical methods;
  • ischaemic heart disease;
  • cholesterol reduction

Summary

This chapter contains section titled:

  • Summary Points

  • Clinical and Statistical Heterogeneity

  • Serum Cholesterol Concentration and Risk of Ischaemic Heart Disease

  • Serum Cholesterol Reduction and Risk of Ischaemic Heart Disease

  • Statistical Methods for Investigating Sources of Heterogeneity

  • The Relationship Between Underlying Risk and Treatment Benefit

  • The virtues of Individual Patient Data

  • Conclusions

  • Acknowledgements