Chapter 103. Giucocorticoid-Insensitive Bronchial Asthma

  1. William W. Busse MD1 and
  2. Stephen T. Holgate BSc, MD, FRCP2
  1. Tak H. Lee and
  2. Donald Y.M. Leung

Published Online: 16 APR 2008

DOI: 10.1002/9780470694923.ch33

Asthma and Rhinitis, Second Edition

Asthma and Rhinitis, Second Edition

How to Cite

Lee, T. H. and Leung, D. Y.M. (2000) Giucocorticoid-Insensitive Bronchial Asthma, in Asthma and Rhinitis, Second Edition (eds W. W. Busse and S. T. Holgate), Blackwell Science Ltd, Oxford, UK. doi: 10.1002/9780470694923.ch33

Editor Information

  1. 1

    Professor of Medicine Head, Clinical Immunology, University of Wisconsin-Madison Medical School, Department of Medicine, Madison Wisconsin, USA

  2. 2

    Clinical Professor of Immuno-Pharmacology, Medical Specialties, Southampton General Hospital, Youthampton, UK

Publication History

  1. Published Online: 16 APR 2008
  2. Published Print: 1 JAN 2000

ISBN Information

Print ISBN: 9780632041756

Online ISBN: 9780470694923



  • glucocorticoids;
  • asthma;
  • epidermis;
  • cytokines;
  • hypothalamic-pituitary axis


This chapter contains section titled:

  • Introduction

  • Molecular Mechanisms of Glucocorticoid Action

  • Transcriptional Interference by the Glucocorticoid Receptor

  • Glucocorticoids Interfere with Ap-1 Activity

  • Inhibition of NF-KB Activation by Glucocorticoids

  • Glucocorticoid-Induced I-KBa Synthesis Inhibits NF-KB Activity

  • Primary Glucocorticoid Resistance

  • Glucocorticoid Insensitivity in Asthma

  • Glucocorticoid Bioavailability in Glucocorticoidinsensitive Asthma

  • Cellular Immune Responses in Glucocorticoidinsensitive Asthma

  • Induction of Glucocorticoid Insensitivity in Vitro

  • Binding of Glucocorticoid Receptor to Glucocorticoid-Response Elements on DNA

  • Increased Expression of GCRP in Glucocorticoidinsensitive Asthma

  • Allergen Exposure and Glucocorticoid-Receptor Binding Affinity

  • Glucocorticoid Resistance in Other Tissues in Glucocorticoid-Insensitive Asthma

  • Hypothalamic-Pituitary-Adrenal Axis in Glucocorticoid-Insensitive Asthma

  • Bone Metabolism in Glucocorticoid-Insensitive Asthma

  • Conclusions

  • References