Chapter 112. Drug Delivery Devices and Propellants

  1. William W. Busse MD1 and
  2. Stephen T. Holgate BSc, MD, FRCP2
  1. Myrna Dolovich and
  2. Chet Leach

Published Online: 16 APR 2008

DOI: 10.1002/9780470694923.ch42

Asthma and Rhinitis, Second Edition

Asthma and Rhinitis, Second Edition

How to Cite

Dolovich, M. and Leach, C. (2000) Drug Delivery Devices and Propellants, in Asthma and Rhinitis, Second Edition (eds W. W. Busse and S. T. Holgate), Blackwell Science Ltd, Oxford, UK. doi: 10.1002/9780470694923.ch42

Editor Information

  1. 1

    Professor of Medicine Head, Clinical Immunology, University of Wisconsin-Madison Medical School, Department of Medicine, Madison Wisconsin, USA

  2. 2

    Clinical Professor of Immuno-Pharmacology, Medical Specialties, Southampton General Hospital, Youthampton, UK

Publication History

  1. Published Online: 16 APR 2008
  2. Published Print: 1 JAN 2000

ISBN Information

Print ISBN: 9780632041756

Online ISBN: 9780470694923



  • drug delivery devices;
  • inhaled medication;
  • aerosol delivery system;
  • hydrofluoroalkane;
  • asthma


This chapter contains section titled:

  • Introduction

  • Factors Influencing the Safety and Efficacy of Drugs Delivered from Pressurized Metered-Dose Inhalers

  • Hydrofluoroalkane and Chlorofluorocarbon Pressurized Metered-Dose Inhalers

  • Active Drug

  • Propellants

  • Co-Solvents

  • Surfactants

  • Other Excipients

  • Mechanical Factors Influencing Drug Delivery

  • Spacers

  • Patient Factors

  • Dry Powder Inhalers

  • Nebulizers

  • Conclusions

  • References