Chapter 26. Targeted Genetic Therapy for Lung Cancer

  1. Jack A. Roth MD, F.A.C.S.1,
  2. James D. Cox MD2 and
  3. Waun Ki Hong MD, D.M.Sc. (Hon.)3
  1. Jack A. Roth

Published Online: 16 APR 2008

DOI: 10.1002/9780470696330.ch26

Lung Cancer, Third Edition

Lung Cancer, Third Edition

How to Cite

Roth, J. A. (2008) Targeted Genetic Therapy for Lung Cancer, in Lung Cancer, Third Edition (eds J. A. Roth, J. D. Cox and W. K. Hong), Blackwell Publishing Ltd, Oxford, UK. doi: 10.1002/9780470696330.ch26

Editor Information

  1. 1

    Professor and Bud Johnson Clinical Distinguished Chair, Department of Thoracic and Cardiovascular Surgery, Professor of Molecular and Cellular Oncology, Director, W.M. Keck Center for Innovative Cancer Therapies, Chief, Section of Thoracic Molecular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

  2. 2

    Professor and Head, Division of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

  3. 3

    American Cancer Society Professor, Samsung Distinguished University Chair in Cancer Medicine, Professor and Head, Division of Cancer Medicine Professor, Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

Publication History

  1. Published Online: 16 APR 2008
  2. Published Print: 1 JAN 2008

ISBN Information

Print ISBN: 9781405151122

Online ISBN: 9780470696330

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Keywords:

  • lung cancer;
  • genetic therapy;
  • cancer cell;
  • chemotherapy;
  • DNA damaging

Summary

This chapter contains section titled:

  • Mechanism of p53 Tumor Suppression and Rationale for p53 Gene Therapy

  • Gene Replacement in Combination with Conventional DNA Damaging Agents in NSCLC

  • Clinical Trials of Tumor Suppressor Gene Replacement Combined with Chemotherapy

  • Clinical Trials of p53 Gene Replacement Combined with Radiation Therapy

  • Systemic Gene Therapy for Metastases

  • Summary and Conclusions

  • References