Chapter 5. Management of Elevated Low-Density Lipoprotein Cholesterol

  1. Peter P. Toth M.D., PH.D. Director of Preventive Cardiology Chief of Medicine Clinical Associate Professor1,2,3,4,
  2. Kevin C. Maki PH.D. President Chief Science Officer5

Published Online: 1 OCT 2008

DOI: 10.1002/9780470696873.ch5

Book Title

Practical Lipid Management: Concepts and Controversies

Practical Lipid Management: Concepts and Controversies

Additional Information

How to Cite

Toth, P. P. and Maki, K. C. (2008) Management of Elevated Low-Density Lipoprotein Cholesterol , in Practical Lipid Management: Concepts and Controversies, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470696873.ch5

Author Information

  1. 1

    Sterling Rock Falls Clinic, Ltd., USA

  2. 2

    CGH Medical Center Sterling, Illinois, USA

  3. 3

    Departments of Family and Community Medicine, University of Illinois College of Medicine Peoria, Illinois, USA

  4. 4

    Southern Illinois University School of Medicine, Springfield, Illinois, USA

  5. 5

    Provident Clinical Research & Consulting, Inc., Glen Ellyn, Illinois and Bloomington, Indiana, USA

Publication History

  1. Published Online: 1 OCT 2008
  2. Published Print: 17 OCT 2008

ISBN Information

Print ISBN: 9780470056905

Online ISBN: 9780470696873

SEARCH

CHAPTER TOOLS

Get PDF (452K)

Keywords:

  • low-density lipoprotein cholesterol;
  • LDL-C - primary cholesterol target;
  • carotid artery disease (CAD);
  • multiple risk factor intervention trial (MRFIT);
  • Lipid Research Clinics Coronary Primary Prevention Trial (LRC-CPPT);
  • Heart Protection Study (HPS);
  • elevated LDL-C management;
  • Liver function tests (LFTs) and baseline measurement;
  • aggressive LDL-C reduction

Summary

This chapter contains sections titled:

  • Relationship between LDL-C and Risk for Cardiovascular Events

  • Clinical Trial Support for Very Aggressive LDL-C Reduction for Those at Highest Risk

  • Genetic Disorders Associated with Elevated LDL-C

  • Atherogenic Impact of LDL-C

  • Management of Elevated LDL-C

  • Summary

  • Controversy: How Low Should We Go?

  • Controversy: Risks and Benefits of High-Dose Statin Therapy Versus Combination Lipid Drug Therapy

  • Controversy: Do the Benefits of Low-Density Lipoprotein Cholesterol Reduction Depend Strictly on “How Low You Go” or also on “How You Get There”?

Get PDF (452K)