Chapter 14. Resistance to Chemotherapy Drugs

  1. Sotiris Missailidis
  1. Robert O'Connor and
  2. Laura Breen

Published Online: 7 NOV 2008

DOI: 10.1002/9780470697047.ch14

Anticancer Therapeutics

Anticancer Therapeutics

How to Cite

O'Connor, R. and Breen, L. (2008) Resistance to Chemotherapy Drugs, in Anticancer Therapeutics (ed S. Missailidis), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470697047.ch14

Editor Information

  1. Department of Chemistry and Analytical Sciences, The Open University, Milton Keynes, UK

Author Information

  1. National Institute for Cellular Biotechnology (NICB), Dublin City University, Dublin, Ireland

Publication History

  1. Published Online: 7 NOV 2008
  2. Published Print: 21 NOV 2008

ISBN Information

Print ISBN: 9780470723036

Online ISBN: 9780470697047



  • chemotherapeutic drug resistance;
  • therapeutic index;
  • chemotherapy resistance mechanisms;
  • cellular defence mechanisms;
  • cellular drug targets and response intermediates;
  • drug uptake mechanism alterations;
  • multidrug resistance inhibitors;
  • PARP enzymes and PARP inhibitors;
  • understanding molecular causes of resistance


This chapter contains sections titled:

  • Introduction

  • What are the Factors Limiting the Efficacy of Cancer Chemotherapy Treatment?

  • A Classification of the Important Chemotherapy Resistance Mechanisms

  • Illustrative Mechanisms of Pharmacokinetic Resistance

  • Illustrative Mechanisms of Pharmacodynamic Resistance

  • Conclusion

  • References