Chapter 3. Rational Approaches to Anticancer Drug Design/in silico Drug Development
- Sotiris Missailidis
Published Online: 7 NOV 2008
DOI: 10.1002/9780470697047.ch3
Copyright © 2008 John Wiley & Sons, Ltd
Book Title
Anticancer Therapeutics
Additional Information
How to Cite
Alcaro, S., Artese, A. and Ortuso, F. (2008) Rational Approaches to Anticancer Drug Design/in silico Drug Development, in Anticancer Therapeutics (ed S. Missailidis), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470697047.ch3
Editor Information
Department of Chemistry and Analytical Sciences, The Open University, Milton Keynes, UK
Publication History
- Published Online: 7 NOV 2008
- Published Print: 21 NOV 2008
ISBN Information
Print ISBN: 9780470723036
Online ISBN: 9780470697047
- Summary
- Chapter
Keywords:
- drug development - ‘race with obstacles’;
- Quantitative Structure-Activity Relationships (QSAR) studies;
- Cambridge Structural Database (CSD);
- ligand-based study and aromatase enzyme inhibitors;
- anticancer drug design rational approaches;
- 3D-pharmacophore search;
- stochastic dynamics with energy minimization (SDEM) approach;
- structure-based drug design paradigm and peptide-based targets;
- drug design process and ‘rational drug design’
Summary
This chapter contains sections titled:
Introduction
Approaches to the Drug Discovery Process in Anticancer Research
Ligand-based Examples
Structure-based Examples
Conclusions
References