Chapter 10. Characterization of Estrogen-Active Compounds and Estrogenic Signaling by Global Gene Expression Profiling In Vitro

  1. Saura C. Sahu
  1. Stephanie Simon,
  2. Kathleen Boehme,
  3. Susanne U. Schmidt and
  4. Stefan O. Mueller

Published Online: 14 OCT 2008

DOI: 10.1002/9780470699638.ch10

Toxicogenomics: A Powerful Tool for Toxicity Assessment

Toxicogenomics: A Powerful Tool for Toxicity Assessment

How to Cite

Simon, S., Boehme, K., Schmidt, S. U. and Mueller, S. O. (2008) Characterization of Estrogen-Active Compounds and Estrogenic Signaling by Global Gene Expression Profiling In Vitro, in Toxicogenomics: A Powerful Tool for Toxicity Assessment (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470699638.ch10

Editor Information

  1. Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA

Author Information

  1. Merck Serono, Toxicology, 64271 Darmstadt, Germany

Publication History

  1. Published Online: 14 OCT 2008
  2. Published Print: 10 OCT 2008

ISBN Information

Print ISBN: 9780470518236

Online ISBN: 9780470699638

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Keywords:

  • ER monomers and estrogen response elements (EREs);
  • epidermal growth factor receptor (EGFR);
  • insulin-like growth factor receptor (IGFR);
  • estrogenicity testing cellular models;
  • Affymetrix GeneChipsRin situ synthesis;
  • estrogen-active compounds and estrogenic signaling characterization;
  • mitogen-activated protein kinase (MAPK) pathway;
  • gene expression profiling and estrogen signaling pathway

Summary

This chapter contains sections titled:

  • Introduction

  • Screening Tools for Estrogenic Activity

  • Cellular Models for Estrogenicity Testing

  • Application of Gene Expression Profiling Methods

  • Genomics Methods as Tools for Estrogen Screening

  • Conclusions

  • References