Chapter 14. Use of Toxicogenomics as an Early Predictive Tool for Hepatotoxicity

  1. Saura C. Sahu
  1. Laura Suter

Published Online: 14 OCT 2008

DOI: 10.1002/9780470699638.ch14

Toxicogenomics: A Powerful Tool for Toxicity Assessment

Toxicogenomics: A Powerful Tool for Toxicity Assessment

How to Cite

Suter, L. (2008) Use of Toxicogenomics as an Early Predictive Tool for Hepatotoxicity, in Toxicogenomics: A Powerful Tool for Toxicity Assessment (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470699638.ch14

Editor Information

  1. Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA

Author Information

  1. F. Hoffmann-La Roche Ltd. Grenzacherstrasse, 90/505a, 4070 Basel, Switzerland

Publication History

  1. Published Online: 14 OCT 2008
  2. Published Print: 10 OCT 2008

ISBN Information

Print ISBN: 9780470518236

Online ISBN: 9780470699638

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Keywords:

  • toxicogenomics - hepatotoxicity predictive tool;
  • metabonomics and proton nuclear magnetic resonance (NMR);
  • Chemical Effects in Biological Systems (CEBS);
  • systems toxicology;
  • hepatotoxicity testing approach and gene expression analysis;
  • In vitro toxicogenomics and toxicological endpoints;
  • in vitro primary hepatocytes and in vivotoxicogenomics;
  • (support vector machines (SVMs)) and recursive feature elimination

Summary

This chapter contains sections titled:

  • Introduction

  • Managing Expectations

  • Technologies

  • Systems Toxicology

  • Timing Is Everything

  • In Vitro Toxicogenomics

  • In Vivo Toxicogenomics

  • Consortia on the Use of ‘Omics’ for the Prediction of Hepatotoxicity

  • Conclusions

  • References