Chapter 16. Application of Toxicogenomics in Drug Discovery

  1. Saura C. Sahu
  1. Michael J. Liguori,
  2. Amy C. Ditewig and
  3. Jeffrey F. Waring

Published Online: 14 OCT 2008

DOI: 10.1002/9780470699638.ch16

Toxicogenomics: A Powerful Tool for Toxicity Assessment

Toxicogenomics: A Powerful Tool for Toxicity Assessment

How to Cite

Liguori, M. J., Ditewig, A. C. and Waring, J. F. (2008) Application of Toxicogenomics in Drug Discovery, in Toxicogenomics: A Powerful Tool for Toxicity Assessment (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470699638.ch16

Editor Information

  1. Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA

Author Information

  1. Abbott Laboratories, Department R4DA, Building AP9A, 100 Abbot Park Rd, Abbott Park, IL 60064, USA

Publication History

  1. Published Online: 14 OCT 2008
  2. Published Print: 10 OCT 2008

ISBN Information

Print ISBN: 9780470518236

Online ISBN: 9780470699638

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Keywords:

  • toxicogenomics and drug discovery;
  • pharmaceutical industry and toxicogenomic screening;
  • NMEs toxicogenomic identification;
  • constitutive androstane receptor (CAR) signaling;
  • hepatic P450 induction or repression;
  • hepatic toxicogenomics;
  • toxicogenomic analysis and whole blood;
  • PPAR pathways and aryl hydrocarbon signaling;
  • human cell culture system toxicogenomics

Summary

This chapter contains sections titled:

  • Introduction

  • Toxicogenomics Objectives and Study Design

  • Toxicogenomics as a Predictive Tool

  • In vivo Toxicogenomics Using Liver as a Target Organ for Characterizing Mechanisms of Toxicity

  • Monitoring Expression Changes of Drug Metabolizing Enzymes Using Genomics

  • Application of In Vivo Toxicogenomics to Nonhepatic Tissues

  • In vitro Toxicogenomics

  • Toxicogenomics of Human Cell Culture Systems

  • Use of Toxicogenomics for Detection of Idiosyncratic Drug Reactions

  • Use of Toxicogenomics to Further Characterize Potential Animal Models

  • Use of In Vitro Toxicogenomics for Understanding IDRs

  • Summary

  • References