Chapter 18. The Development of a Metabonomic-Based Drug Safety Testing Paradigm

  1. Saura C. Sahu
  1. Muireann Coen,
  2. Elaine Holmes,
  3. Jeremy K. Nicholson and
  4. John C. Lindon

Published Online: 14 OCT 2008

DOI: 10.1002/9780470699638.ch18

Toxicogenomics: A Powerful Tool for Toxicity Assessment

Toxicogenomics: A Powerful Tool for Toxicity Assessment

How to Cite

Coen, M., Holmes, E., Nicholson, J. K. and Lindon, J. C. (2008) The Development of a Metabonomic-Based Drug Safety Testing Paradigm, in Toxicogenomics: A Powerful Tool for Toxicity Assessment (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470699638.ch18

Editor Information

  1. Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA

Author Information

  1. Department of Biomolecular Medicine, Sir Alexander Fleming Building, SORA Division, Faculty of Medicine, Imperial College London, SW7 2AZ, UK

Publication History

  1. Published Online: 14 OCT 2008
  2. Published Print: 10 OCT 2008

ISBN Information

Print ISBN: 9780470518236

Online ISBN: 9780470699638

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Keywords:

  • metabonomic-based drug safety testing paradigm;
  • Consortium on Metabonomic Toxicology (COMET) projects;
  • metabonomic expert system;
  • metabonomics and NMR and HPLC–MS;
  • O-PLS-DA modeling and ‘binned’ UPLC–MS data;
  • multivariate statistical batch processing and NMR spectral data;
  • COnsortium on MEtabonomic Toxicology (COMET-2);
  • pharmacometabonomics - pre-dose metabolite profile response prediction

Summary

This chapter contains sections titled:

  • Introduction

  • Analytical Platforms Utilized for Metabonomics

  • Statistical Tools Applied to Model Metabonomic Data

  • Integrated Metabonomic and ‘Multi-omic’ Studies

  • COMET: A Consortium Project Using NMR-driven Metabonomics

  • The COMET-2 Project

  • Prospects for the Future

  • Concluding Remarks

  • References