Chapter 4. Design Issues in Toxicogenomics: The Application of Genomic Technologies for Mechanistic and Predictive Research

  1. Saura C. Sahu
  1. Woong-Yang Park1,
  2. Lian Li2 and
  3. Daehee Kang3

Published Online: 14 OCT 2008

DOI: 10.1002/9780470699638.ch4

Toxicogenomics: A Powerful Tool for Toxicity Assessment

Toxicogenomics: A Powerful Tool for Toxicity Assessment

How to Cite

Park, W.-Y., Li, L. and Kang, D. (2008) Design Issues in Toxicogenomics: The Application of Genomic Technologies for Mechanistic and Predictive Research, in Toxicogenomics: A Powerful Tool for Toxicity Assessment (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470699638.ch4

Editor Information

  1. Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA

Author Information

  1. 1

    Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 110-799, Korea

  2. 2

    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 110-799, Korea

  3. 3

    Molecular and Genomic Epidemiology Laboratory (MGEL), Seoul National University College of Medicine, 103 Daehangno, Chongnogu, Seoul 110-799, Korea

Publication History

  1. Published Online: 14 OCT 2008
  2. Published Print: 10 OCT 2008

ISBN Information

Print ISBN: 9780470518236

Online ISBN: 9780470699638

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Keywords:

  • toxicogenomic design issue;
  • toxicogenomic adverse toxic effect prediction;
  • personal genome sequencing;
  • methylated DNA immunoprecipitation (MeDIP) and genomic DNA arrays;
  • basal cytotoxicity chemical reaction;
  • epidemiological study design - cohort and case–control studies;
  • toxicogenomic research application;
  • microarray genome-wide analysis

Summary

This chapter contains sections titled:

  • Introduction

  • Genomic Technologies

  • Hierachy of Toxicogenomic Studies

  • Application of Toxicogenomic Research

  • Conclusion

  • Acknowledgments

  • References