Chapter 5. Sources of Variability in Toxicogenomic Assays

  1. Saura C. Sahu
  1. Karol Thompson,
  2. P. Scott Pine and
  3. Barry Rosenzweig

Published Online: 14 OCT 2008

DOI: 10.1002/9780470699638.ch5

Toxicogenomics: A Powerful Tool for Toxicity Assessment

Toxicogenomics: A Powerful Tool for Toxicity Assessment

How to Cite

Thompson, K., Pine, P. S. and Rosenzweig, B. (2008) Sources of Variability in Toxicogenomic Assays, in Toxicogenomics: A Powerful Tool for Toxicity Assessment (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470699638.ch5

Editor Information

  1. Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA

Author Information

  1. Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA

Publication History

  1. Published Online: 14 OCT 2008
  2. Published Print: 10 OCT 2008

ISBN Information

Print ISBN: 9780470518236

Online ISBN: 9780470699638

SEARCH

Keywords:

  • toxicogenomic assay and source variability;
  • Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways;
  • Microarray Quality Control (MAQC) Consortium;
  • HESI Technical Committee and doxorubicin cardiotoxicity;
  • RNA integrity effect and microarray data sensitivity;
  • toxicogenomic study design RNA quality threshold;
  • signal uniformity across array assessment

Summary

This chapter contains sections titled:

  • Introduction

  • The Importance of Study Design

  • The Effect of RNA Quality on Toxicogenomic Data

  • Optimizing Laboratory Protocols

  • Summary

  • Disclaimer

  • References