Chapter 7. Toxicogenomics as a Tool to Assess Immunotoxicity

  1. Saura C. Sahu
  1. Kirsten A. Baken1,2,
  2. Janine Ezendam3,
  3. Jeroen L. A. Pennings3,
  4. Rob J. Vandebriel3 and
  5. Henk van Loveren3

Published Online: 14 OCT 2008

DOI: 10.1002/9780470699638.ch7

Toxicogenomics: A Powerful Tool for Toxicity Assessment

Toxicogenomics: A Powerful Tool for Toxicity Assessment

How to Cite

Baken, K. A., Ezendam, J., Pennings, J. L. A., Vandebriel, R. J. and van Loveren, H. (2008) Toxicogenomics as a Tool to Assess Immunotoxicity, in Toxicogenomics: A Powerful Tool for Toxicity Assessment (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470699638.ch7

Editor Information

  1. Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD 20708, USA

Author Information

  1. 1

    Department of Health Risk Analysis and Toxicology (GRAT), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands

  2. 2

    Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands

  3. 3

    Laboratory for Health Protection Research, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands

Publication History

  1. Published Online: 14 OCT 2008
  2. Published Print: 10 OCT 2008

ISBN Information

Print ISBN: 9780470518236

Online ISBN: 9780470699638

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Keywords:

  • immunotoxicology gene expression profiling application;
  • Hexachlorobenzene (HCB) - environmental pollutant;
  • xenobiotic 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD);
  • Bis(tri-n-butyltin)oxide (TBTO);
  • toxicogenomics tool assessing immunotoxicity;
  • gene expression immunotoxicant change;
  • polycyclic aromatic hydrocarbons (PAHs);
  • screening assay development;
  • immunotoxicity evaluation and toxicogenomic application

Summary

This chapter contains sections titled:

  • Introduction

  • Applications of Gene Expression Profiling in Immunotoxicology

  • Lessons from Immunotoxicogenomics Studies

  • Conclusion

  • References