1. Green Toxicology

  1. Wei Zhang2 and
  2. Berkeley W. Cue Jr.3
  1. Nicholas D. Anastas

Published Online: 29 MAY 2012

DOI: 10.1002/9780470711828.ch1

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry

How to Cite

Anastas, N. D. (2012) Green Toxicology, in Green Techniques for Organic Synthesis and Medicinal Chemistry (eds W. Zhang and B. W. Cue), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470711828.ch1

Editor Information

  1. 2

    Center for Green Chemistry, Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts, USA

  2. 3

    BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Author Information

  1. Poseidon's Trident, LLC, Milton, Massachusetts, USA

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 22 JUN 2012

ISBN Information

Print ISBN: 9780470711514

Online ISBN: 9780470711828



  • Green toxicology, environmental chemodynamics and ecological toxicology;
  • structure–hazard relationship, molecular design and toxicology;
  • toxicology, as pharmacology at high doses;
  • systems biology, toxicity in a more holistic way;
  • toxicant and reversible toxicity potential;
  • chemicals and threshold response;
  • dose–response relationship and dose–response curve;
  • immunotoxicity, as hypersensitivity or allergic reactions;
  • mechanistic toxicology, molecular events and adverse outcomes;
  • QSARs, predicting responses of untested molecules


This chapter contains sections titled:

  • Introduction

  • History and Scope of Toxicology

  • Principles of Toxicology

  • Disposition of Toxicants in Organisms

  • Non-Organ System Toxicity

  • Mechanistic Toxicology

  • Quantitative Structure–Activity Relationships

  • Environmental Toxicology

  • Risk Assessment

  • Conclusions

  • References