10. Organic Synthesis in Water

  1. Wei Zhang2 and
  2. Berkeley W. Cue Jr.3
  1. Marc-Olivier Simon and
  2. Chao-Jun Li

Published Online: 29 MAY 2012

DOI: 10.1002/9780470711828.ch10

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry

How to Cite

Simon, M.-O. and Li, C.-J. (2012) Organic Synthesis in Water, in Green Techniques for Organic Synthesis and Medicinal Chemistry (eds W. Zhang and B. W. Cue), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470711828.ch10

Editor Information

  1. 2

    Center for Green Chemistry, Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts, USA

  2. 3

    BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Author Information

  1. Department of Chemistry, McGill University, Montreal, Quebec, Canada

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 22 JUN 2012

ISBN Information

Print ISBN: 9780470711514

Online ISBN: 9780470711828



  • organic synthesis in water;
  • organic synthesis in water, a promising field;
  • water, and sustainability advantages;
  • pericyclic reactions, bonds and stereogenic centres;
  • “On water” accelerated Diels–Alder reaction;
  • Claisen rearrangements, acceleration using water as reaction media;
  • nucleophilic ring-opening reactions;
  • transition metal catalyzed reactions, in aqueous media;
  • coupling reactions, tools for carbon–carbon and carbon–heteroatom bonds;
  • water as solvent for target-guided synthesis and click chemistry


This chapter contains sections titled:

  • Introduction

  • Pericyclic Reactions

  • Passerini and Ugi Reactions

  • Nucleophilic Ring-Opening Reactions

  • Transition Metal Catalyzed Reactions

  • Organocatalytic Reactions

  • Miscellaneous

  • Conclusion

  • References