11. Solvent-Free Synthesis

  1. Wei Zhang3 and
  2. Berkeley W. Cue Jr.4
  1. James Mack1 and
  2. Sivaramakrishnan Muthukrishnan2

Published Online: 29 MAY 2012

DOI: 10.1002/9780470711828.ch11

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry

How to Cite

Mack, J. and Muthukrishnan, S. (2012) Solvent-Free Synthesis, in Green Techniques for Organic Synthesis and Medicinal Chemistry (eds W. Zhang and B. W. Cue), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470711828.ch11

Editor Information

  1. 3

    Center for Green Chemistry, Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts, USA

  2. 4

    BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Author Information

  1. 1

    University of Cincinnati, Cincinnati, Ohio, USA

  2. 2

    Strategic Innovation & Technology, Procter & Gamble Co., Cincinnati, Ohio, USA

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 22 JUN 2012

ISBN Information

Print ISBN: 9780470711514

Online ISBN: 9780470711828

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Keywords:

  • solvent-free synthesis;
  • alternative methods to solution based synthesis;
  • planetary and vibratory mills, for solvent-free chemical reactions;
  • ball milling reactions in two-step, activation step and ignition step;
  • carbonyl based solvent-free reactions, using ball milling;
  • Sonogashira reaction, solvent-free high speed ball milling;
  • solvent-free ball milling conditions and “Click” chemistry

Summary

This chapter contains sections titled:

  • Introduction

  • Alternative Methods to Solution Based Synthesis

  • References