15. Solid-Supported Synthesis

  1. Wei Zhang2 and
  2. Berkeley W. Cue Jr.3
  1. Gorakh S. Yellol and
  2. Chung-Ming Sun

Published Online: 29 MAY 2012

DOI: 10.1002/9780470711828.ch15

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry

How to Cite

Yellol, G. S. and Sun, C.-M. (2012) Solid-Supported Synthesis, in Green Techniques for Organic Synthesis and Medicinal Chemistry (eds W. Zhang and B. W. Cue), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470711828.ch15

Editor Information

  1. 2

    Center for Green Chemistry, Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts, USA

  2. 3

    BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Author Information

  1. Laboratory of Combinatorial Drug Discovery, Department of Applied Chemistry, National Chiao-Tung University, Hsinchu, Taiwan

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 22 JUN 2012

ISBN Information

Print ISBN: 9780470711514

Online ISBN: 9780470711828



  • solid-supported synthesis;
  • solid-supported, a green synthesis eliminating complicated workup;
  • solid-phase synthetic with combinatorial chemistry, in drug discovery;
  • new synthetic methodologies, for solid-supported synthesis;
  • general polymer-supported synthesis approach;
  • linkers, role in solid-supported synthesis;
  • solid-supported synthesis, and automated synthesis of compound libraries;
  • solid-supported synthesis, using the split and combine technique;
  • “Solid-supported synthesis of heterocyclic molecules” as green technique;
  • multidisciplinary synthetic approach, and rapid synthesis


This chapter contains sections titled:

  • Introduction

  • Techniques of Solid-Supported Synthesis

  • Solid-Supported Heterocyclic Chemistry

  • Solid-Supported Natural Products Synthesis

  • Solid-Supported Synthesis of Peptides and Carbohydrates

  • Soluble-Supported Synthesis

  • Multidisciplinary Synthetic Approaches

  • References