18. Multicomponent Reactions

  1. Wei Zhang2 and
  2. Berkeley W. Cue Jr.3
  1. Yijun Huang,
  2. Ahmed Yazbak and
  3. Alexander Dömling

Published Online: 29 MAY 2012

DOI: 10.1002/9780470711828.ch18

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry

How to Cite

Huang, Y., Yazbak, A. and Dömling, A. (2012) Multicomponent Reactions, in Green Techniques for Organic Synthesis and Medicinal Chemistry (eds W. Zhang and B. W. Cue), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470711828.ch18

Editor Information

  1. 2

    Center for Green Chemistry, Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts, USA

  2. 3

    BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Author Information

  1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 22 JUN 2012

ISBN Information

Print ISBN: 9780470711514

Online ISBN: 9780470711828



  • MCR, closely approaching concept of “ideal synthesis”;
  • green chemistry, and sustainability;
  • MCR, materials reacting, incorporating atoms of the educts;
  • MCRs, and advantages in drug discovery;
  • MCR chemistry, as the prototypical green chemistry;
  • MCR acceleration in water;
  • MCR “on water,” as an “on water” reaction;
  • solvent-free organic, for clean, safe, easy to perform procedures;
  • MCRs, new approach to efficient synthesis of diverse compound libraries;
  • SFC in pharmaceutical industry, and solvent saving


This chapter contains sections titled:

  • Introduction

  • Multicomponent Reactions in Aqueous Medium

  • Solventless Multicomponent Reactions

  • Case Studies of Multicomponent Reactions in Drug Synthesis

  • Perspectives of Multicomponent Reactions in Green Chemistry

  • Outlook

  • References