19. Flow Reactors

  1. Wei Zhang4 and
  2. Berkeley W. Cue Jr.5
  1. Frédéric G. Buono1,
  2. Michael A. Gonzalez2 and
  3. Jale Müslehiddinoğlu3

Published Online: 29 MAY 2012

DOI: 10.1002/9780470711828.ch19

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry

How to Cite

Buono, F. G., Gonzalez, M. A. and Müslehiddinoğlu, J. (2012) Flow Reactors, in Green Techniques for Organic Synthesis and Medicinal Chemistry (eds W. Zhang and B. W. Cue), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470711828.ch19

Editor Information

  1. 4

    Center for Green Chemistry, Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts, USA

  2. 5

    BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Author Information

  1. 1

    Boehringer Ingelheim, Ridgefield, Connecticut, USA

  2. 2

    United States Environmental Protection Agency, National Risk Management Research Laboratory, Cincinnati, Ohio, USA

  3. 3

    Infinity Pharmaceuticals Inc., Cambridge, Massachusetts, USA

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 22 JUN 2012

ISBN Information

Print ISBN: 9780470711514

Online ISBN: 9780470711828



  • flow reactors, with alternative reactor configurations, geometries;
  • Winterton's 12 additional principles of green chemistry;
  • flow reactors and miniaturization, for PI, novel process window approach;
  • PI benefits, less operating and material cost, minimized environmental impact;
  • flow reactor features on flow chemistry impact on process greenness;
  • microreactors regardless of MOC, efficient heat removal;
  • specifications of selected microreactors;
  • flow technology focus on waste prevention, and yield improvement;
  • TEMPO-catalyzed oxidation reaction, for pharmaceutical synthesis


This chapter contains sections titled:

  • Introduction

  • Types of Flow Reactors

  • Application of Flow Reactors

  • Conclusion

  • Acknowledgment

  • References