20. Green Chemistry Strategies for Medicinal Chemists

  1. Wei Zhang1 and
  2. Berkeley W. Cue Jr.2
  1. Berkeley W. Cue Jr.

Published Online: 29 MAY 2012

DOI: 10.1002/9780470711828.ch20

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry

How to Cite

Cue, B. W. (2012) Green Chemistry Strategies for Medicinal Chemists, in Green Techniques for Organic Synthesis and Medicinal Chemistry (eds W. Zhang and B. W. Cue), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470711828.ch20

Editor Information

  1. 1

    Center for Green Chemistry, Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts, USA

  2. 2

    BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Author Information

  1. BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 22 JUN 2012

ISBN Information

Print ISBN: 9780470711514

Online ISBN: 9780470711828

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Keywords:

  • green techniques in pharmaceutical industry;
  • green chemistry strategies for medicinal chemists;
  • green chemistry, and commitment to a healthy environment;
  • medicinal or discovery chemistry, greening synthetic chemistry;
  • green chemistry in process chemistry, manufacturing and medicinal chemistry;
  • PhRMA companies, assessing their GC activities;
  • the best green, with E-factor, solvent utilization and GC BHAGs;
  • Pfizer's chemists, solvent selection tools, as preferred, allowed, discouraged;
  • Pfizer's solvent guide, green (preferred), yellow (useable) and red (undesirable)

Summary

This chapter contains sections titled:

  • Introduction

  • Historical Background: The Evolution of Green Chemistry in the Pharmaceutical Industry

  • Green Chemistry in Process Chemistry, Manufacturing and Medicinal Chemistry and Barriers to Rapid Uptake

  • Green Chemistry Activity Among PhRMA Member Companies

  • Modeling Waste Generation in Pharmaceutical R&D

  • Strategies to Reduce the Use of Solvents

  • Green Reactions for Medicinal Chemistry

  • Modeling Waste Co-Produced During R&D Synthesis

  • Green Chemistry and Drug Design: Benign by Design

  • Green Biology

  • Conclusions and Recommendations

  • References