22. Preparative Chromatography

  1. Wei Zhang3 and
  2. Berkeley W. Cue Jr.4
  1. Kathleen Mihlbachler1 and
  2. Olivier Dapremont2

Published Online: 29 MAY 2012

DOI: 10.1002/9780470711828.ch22

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry

How to Cite

Mihlbachler, K. and Dapremont, O. (2012) Preparative Chromatography, in Green Techniques for Organic Synthesis and Medicinal Chemistry (eds W. Zhang and B. W. Cue), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470711828.ch22

Editor Information

  1. 3

    Center for Green Chemistry, Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts, USA

  2. 4

    BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Author Information

  1. 1

    Otto H. York Department of Chemical, Biological and Pharmaceutical Engineering, New Jersey Institute of Technology, Newark, New Jersey, USA

  2. 2

    AMPAC Fine Chemicals, Rancho Cordova, California, USA

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 22 JUN 2012

ISBN Information

Print ISBN: 9780470711514

Online ISBN: 9780470711828



  • preparative chromatography;
  • preparative chromatography for intermediates and APIs;
  • chiral separations;
  • chromatography, and 12 Principles of GC;
  • chromatography systems, elution modes;
  • supercritical fluid chromatography;
  • process chromatography, SMB for chiral resolution;
  • global process optimization, synthesis and impurity removal;
  • chromatography versus crystallization, removing genotoxic impurity;
  • SMB mining, product from waste stream


This chapter contains sections titled:

  • Introduction

  • Preparative Chromatography for Intermediates and APIs

  • Chromatography and the 12 Principles of Green Chemistry

  • Overview of Chromatography Systems

  • Examples of Process Chromatography

  • Conclusions

  • References