24. Green Process Chemistry in the Pharmaceutical Industry: Recent Case Studies

  1. Wei Zhang2 and
  2. Berkeley W. Cue Jr.3
  1. Ji Zhang1 and
  2. Berkeley W. Cue Jr.3

Published Online: 29 MAY 2012

DOI: 10.1002/9780470711828.ch24

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry

How to Cite

Zhang, J. and Cue, B. W. (2012) Green Process Chemistry in the Pharmaceutical Industry: Recent Case Studies, in Green Techniques for Organic Synthesis and Medicinal Chemistry (eds W. Zhang and B. W. Cue), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470711828.ch24

Editor Information

  1. 2

    Center for Green Chemistry, Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts, USA

  2. 3

    BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Author Information

  1. 1

    King Kai-Ray Pharmaceuticals, LLC, Princeton, New Jersey, USA

  2. 3

    BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 22 JUN 2012

ISBN Information

Print ISBN: 9780470711514

Online ISBN: 9780470711828

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Keywords:

  • green process chemistry in pharmaceutical industry;
  • sitagliptin, green to greener, catalytic to metal-free enzymatic;
  • saxagliptin, biocatalytic approach eliminating toxic chemical;
  • armodafinil, classical resolution to catalytic asymmetric oxidation;
  • emend, redesigned for the green process;
  • greening a process via one-pot, or telescoped processing;
  • greening a process via salt formation;
  • chiral phase-transfer catalysis

Summary

This chapter contains sections titled:

  • Introduction

  • Sitagliptin: From Green to Greener; from a Catalytic Reaction to a Metal-Free Enzymatic Process

  • Saxagliptin: Elimination of Toxic Chemicals and the Use of a Biocatalytic Approach

  • Armodafinil: From Classical Resolution to Catalytic Asymmetric Oxidation to Maximize the Output

  • Emend: Redesigned for the Green Process

  • Greening a Process via One-Pot or Telescoped Processing

  • Greening a Process via Salt Formation

  • Metal-free Organocatalysis: Applications of Chiral Phase-transfer Catalysis

  • Conclusions

  • References