25. Green Analytical Chemistry

  1. Wei Zhang4 and
  2. Berkeley W. Cue Jr.5
  1. Paul Ferguson1,
  2. Mark Harding2 and
  3. Jennifer Young3

Published Online: 29 MAY 2012

DOI: 10.1002/9780470711828.ch25

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry

How to Cite

Ferguson, P., Harding, M. and Young, J. (2012) Green Analytical Chemistry, in Green Techniques for Organic Synthesis and Medicinal Chemistry (eds W. Zhang and B. W. Cue), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470711828.ch25

Editor Information

  1. 4

    Center for Green Chemistry, Department of Chemistry, University of Massachusetts Boston, Boston, Massachusetts, USA

  2. 5

    BWC Pharma Consulting, LLC, Green Chemistry and Pharmaceutical Sciences, Ledyard, Connecticut, USA

Author Information

  1. 1

    Research Analytics, Pfizer Global Research & Development, Sandwich, Kent, UK

  2. 2

    Development Analytics, Pfizer Global Research & Development, Sandwich, Kent, UK

  3. 3

    ACS Green Chemistry Institute1, American Chemical Society, Washington, DC, USA

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 22 JUN 2012

ISBN Information

Print ISBN: 9780470711514

Online ISBN: 9780470711828

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Keywords:

  • GAC, generating less waste, using less hazardous chemicals;
  • three Rs of GAC, and the 12 principles of green chemistry;
  • solvent consumption, ways to reduce, recycle, replace;
  • greenness of analytical method, and principles of GC;
  • the greenness profile symbol;
  • solvents and additives for pH adjustment;
  • Pfizer solvent selection guide for GC;
  • “Green” acids and bases for modifying mobile phase pH/pH;
  • “screening” methods, route to green sample analysis;
  • on-line reaction monitoring using chromatographic systems

Summary

This chapter contains sections titled:

  • Introduction

  • Method Assessment

  • Solvents and Additives for pH Adjustment

  • Sample Preparation

  • Techniques and Methods

  • Conclusions

  • Acknowledgments

  • References