Chapter 10. The Phenomena of Resistance and Dependence in Leukæmic Cells

  1. G. E. W. Wolstenholme O.B.E., M.A., M.B., B.Ch. and
  2. Margaret P. Cameron M.A., A.B.L.S.
  1. L. W. Law

Published Online: 30 MAY 2008

DOI: 10.1002/9780470718902.ch10

Ciba Foundation Symposium - Leukæmia Research

Ciba Foundation Symposium - Leukæmia Research

How to Cite

Law, L. W. (1954) The Phenomena of Resistance and Dependence in Leukæmic Cells, in Ciba Foundation Symposium - Leukæmia Research (eds G. E. W. Wolstenholme and M. P. Cameron), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470718902.ch10

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1954

ISBN Information

Print ISBN: 9780470722336

Online ISBN: 9780470718902

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Keywords:

  • leukæmia;
  • purine antagonists;
  • therapeutic investigations;
  • folic acid;
  • intraperitoneal transfer

Summary

This chapter contains section titled:

  • Folic Acid Analogues

  • Characteristics of Leukæmic Cells Dependent on Folic Analogues for Optimal Growth

  • Possible Mechanisms of Resistance and Dependence

  • Purine Analogues

  • Transformations to Resistance and Dependence using 8-Azaguanine

  • Resistance to an Adenine Antagonist, 6-Mercaptopurine

  • Mode of Action of Purine Antagonists

  • Origin of Resistance in Leukæmic Cells to Antimetabolites

  • Practical Considerations

  • Summary

  • References

  • Discussion