Chapter 15. The Effect of Variation in Experimental Procedure in Amine Carcinogenesis

  1. G. E. W. Wolstenholme O.B.E., M.A., M.B., B.Ch. and
  2. Maeve O'Connor B.A.
  1. Georgiana M. Bonser,
  2. L. Bradshaw,
  3. D. B. Clayson and
  4. J. W. Jull

Published Online: 30 MAY 2008

DOI: 10.1002/9780470719138.ch15

Ciba Foundation Symposium - Carcinogenesis: Mechanisms of Action

Ciba Foundation Symposium - Carcinogenesis: Mechanisms of Action

How to Cite

Bonser, G. M., Bradshaw, L., Clayson, D. B. and Jull, J. W. (1959) The Effect of Variation in Experimental Procedure in Amine Carcinogenesis, in Ciba Foundation Symposium - Carcinogenesis: Mechanisms of Action (eds G. E. W. Wolstenholme and M. O'Connor), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470719138.ch15

Author Information

  1. Department of Experimental Pathology and Cancer Research, Medical School, University of Leeds

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1959

ISBN Information

Print ISBN: 9780470722572

Online ISBN: 9780470719138

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Keywords:

  • bladder cancer;
  • turnours;
  • metabolism;
  • aromatic amines;
  • bladder carcinogens

Summary

The prelims comprise:

  • Testing of 4-aminodiphenyl

  • Testing of other compounds

  • Testing of known polycyclic hydrocarbons by bladder implantation

  • An assessment of the value of bladder implantation as a means of testing chemicals for carcinogenic activity

  • Discussion of the methods used for assessing tumour incidence following bladder implantation

  • Reasons for regarding the tumours as due to the chemical rather than to the presence of a foreign body in the bladder

  • Conclusion