Chapter 4. Extracellular Strategies of a Replicating RNA Genome

  1. G. E. W. Wolstenholme and
  2. Maeve O'Connor
  1. S. Spisgelman

Published Online: 30 MAY 2008

DOI: 10.1002/9780470719824.ch4

Ciba Foundation Symposium - Strategy of the Viral Genome

Ciba Foundation Symposium - Strategy of the Viral Genome

How to Cite

Spisgelman, S. (1971) Extracellular Strategies of a Replicating RNA Genome, in Ciba Foundation Symposium - Strategy of the Viral Genome (eds G. E. W. Wolstenholme and M. O'Connor), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470719824.ch4

Author Information

  1. Institute of Cancer Research, Columbia University, New York

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1971

ISBN Information

Print ISBN: 9780700015252

Online ISBN: 9780470719824

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Keywords:

  • structural proteins;
  • enzymes;
  • cellular information;
  • synthesizing machinery;
  • dna-rna hybridization test

Summary

This chapter contains section titled:

  • The Problems of Communication Between an RNA Virus and its Host Cell

  • The Search for RNA Replicase and Template Specificity

  • The Ms2 Replicase

  • Confirmation of Specific Template Requirements with the Qβ Replicase

  • The Nature of the Product Synthesized

  • Evidence for the Synthesis of an Infectious Viral RNA

  • A Rigorous Proof that the Added RNA is the Self-Duplicating Entity

  • Extracellular Darwinian Experiments with the Replicating RNA Molecules

  • Diverse Variants Isolated Under Differbnt Selective Conditions

  • Some Theoretical and Practical Implications of Extracellular Darwinian Experiments

  • Summary

  • References

  • Discussion