Chapter 10. The Structure of Human Serum Low- and High-Density Lipoproteins

  1. Ruth Porter and
  2. Julie Knight
  1. Angelo M. Scanu

Published Online: 30 MAY 2008

DOI: 10.1002/9780470719954.ch10

Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors

Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors

How to Cite

Scanu, A. M. (2008) The Structure of Human Serum Low- and High-Density Lipoproteins, in Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors (eds R. Porter and J. Knight), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470719954.ch10

Author Information

  1. Department of Medicine and Biochemistry, University of Chicago Pritzker School of Medicine and Argonne Cancer Research Hospital

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1973

ISBN Information

Print ISBN: 9789021940137

Online ISBN: 9780470719954

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Keywords:

  • human serum;
  • high-density lipoproteins;
  • protein moieties;
  • phospholipid;
  • polyglycerophosphatides

Summary

An analysis is presented of current information on the structure of human serum low- and high-density lipoproteins. Studies on their protein moieties are outlined, particularly those on their polypeptide composition and properties. Re-assembly studies using these polypeptides and natural or synthetic lipids are discussed with particular emphasis on the more recent results obtained by physical, chemical and immunological techniques. Recently proposed structural models of low-and high-density lipoproteins are critically analysed in light of the more recent acquisitions in the field.