Chapter 2. Tissue Changes and Lipid Entry in Developing Atheroma
- Ruth Porter,
- Julie Knight
Published Online: 30 MAY 2008
DOI: 10.1002/9780470719954.ch2
Copyright © 1973 Ciba Foundation
Book Title
Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors
Additional Information
How to Cite
Adams, C. W. M. (2008) Tissue Changes and Lipid Entry in Developing Atheroma, in Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors (eds R. Porter and J. Knight), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470719954.ch2
Publication History
- Published Online: 30 MAY 2008
- Published Print: 1 JAN 1973
Book Series:
ISBN Information
Print ISBN: 9789021940137
Online ISBN: 9780470719954
- Summary
- Chapter
- References
Keywords:
- atheroma;
- sterol-induced fibrosis;
- cholesterol esterification;
- tissue changes;
- tunica intima
Summary
The development of atherosclerosis is discussed from the following aspects. 1. The cause of the sclerosis: platelet and fibrin encrustation, haemo-dynamic stress and sterol-induced fibrosis. 2. Lipid accumulation: accumulation of esterified cholesterol and relative absence of triglycerides, hydrolysis of triglycerides by the aortic wall lipase, cholesterol esterification, the role of acid-mucosubstances as a lipid trap, and ischaemia of the media. 3. Lipid entry: endothelial entry; detection of lipoprotein-bound cholesterol in the arterial intima, influx of protein and lipid into the arterial wall, role of endothelial damage in promoting increased permeability, the metabolic inertia of cholesterol in the atheromatous intima and the therapeutic implications of this inertia.