Chapter 2. Tissue Changes and Lipid Entry in Developing Atheroma

  1. Ruth Porter and
  2. Julie Knight
  1. C. W. M. Adams

Published Online: 30 MAY 2008

DOI: 10.1002/9780470719954.ch2

Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors

Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors

How to Cite

Adams, C. W. M. (2008) Tissue Changes and Lipid Entry in Developing Atheroma, in Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors (eds R. Porter and J. Knight), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470719954.ch2

Author Information

  1. Department of Pathology, Guy's Hospital Medical School, London

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1973

ISBN Information

Print ISBN: 9789021940137

Online ISBN: 9780470719954

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Keywords:

  • atheroma;
  • sterol-induced fibrosis;
  • cholesterol esterification;
  • tissue changes;
  • tunica intima

Summary

The development of atherosclerosis is discussed from the following aspects. 1. The cause of the sclerosis: platelet and fibrin encrustation, haemo-dynamic stress and sterol-induced fibrosis. 2. Lipid accumulation: accumulation of esterified cholesterol and relative absence of triglycerides, hydrolysis of triglycerides by the aortic wall lipase, cholesterol esterification, the role of acid-mucosubstances as a lipid trap, and ischaemia of the media. 3. Lipid entry: endothelial entry; detection of lipoprotein-bound cholesterol in the arterial intima, influx of protein and lipid into the arterial wall, role of endothelial damage in promoting increased permeability, the metabolic inertia of cholesterol in the atheromatous intima and the therapeutic implications of this inertia.