Chapter 8. Possible Role of the Glycosaminoglycans in the Genesis of Atherosclerosis

  1. Ruth Porter and
  2. Julie Knight
  1. Per-Henrik Iverius

Published Online: 30 MAY 2008

DOI: 10.1002/9780470719954.ch8

Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors

Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors

How to Cite

Iverius, P.-H. (2008) Possible Role of the Glycosaminoglycans in the Genesis of Atherosclerosis, in Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors (eds R. Porter and J. Knight), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470719954.ch8

Author Information

  1. Institute of Medical Chemistry, University of Uppsula

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1973

ISBN Information

Print ISBN: 9789021940137

Online ISBN: 9780470719954

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Keywords:

  • atherosclerosis;
  • glycosaminoglycans;
  • lipoproteins;
  • atheroma;
  • mucopolysaccharides

Summary

It is assumed that the lipid deposits in atherosclerosis are formed by a filtration of plasma lipoproteins into the arterial wall. The glycosaminoglycans, which are a major constituent of the intercellular matrix, might aid in such a process by steric as well as ionic interactions with the lipoproteins.

The extracellular glycosaminoglycans are entangled, forming a chain network. When plasma is forced into this, filter effects known as molecular sieving might aid in the enrichment and retention of lipoproteins. Further, one of the glycosaminoglycans, dermatan sulphate, may bind very low-density and low-density lipoproteins by ionic interaction.