Chapter 8. Possible Role of the Glycosaminoglycans in the Genesis of Atherosclerosis
- Ruth Porter,
- Julie Knight
Published Online: 30 MAY 2008
DOI: 10.1002/9780470719954.ch8
Copyright © 1973 Ciba Foundation
Book Title
Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors
Additional Information
How to Cite
Iverius, P.-H. (2008) Possible Role of the Glycosaminoglycans in the Genesis of Atherosclerosis, in Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors (eds R. Porter and J. Knight), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470719954.ch8
Publication History
- Published Online: 30 MAY 2008
- Published Print: 1 JAN 1973
Book Series:
ISBN Information
Print ISBN: 9789021940137
Online ISBN: 9780470719954
- Summary
- Chapter
- References
Keywords:
- atherosclerosis;
- glycosaminoglycans;
- lipoproteins;
- atheroma;
- mucopolysaccharides
Summary
It is assumed that the lipid deposits in atherosclerosis are formed by a filtration of plasma lipoproteins into the arterial wall. The glycosaminoglycans, which are a major constituent of the intercellular matrix, might aid in such a process by steric as well as ionic interactions with the lipoproteins.
The extracellular glycosaminoglycans are entangled, forming a chain network. When plasma is forced into this, filter effects known as molecular sieving might aid in the enrichment and retention of lipoproteins. Further, one of the glycosaminoglycans, dermatan sulphate, may bind very low-density and low-density lipoproteins by ionic interaction.