Chapter 8. Possible Role of the Glycosaminoglycans in the Genesis of Atherosclerosis
- Ruth Porter,
- Julie Knight
Published Online: 30 MAY 2008
Copyright © 1973 Ciba Foundation
Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors
How to Cite
Iverius, P.-H. (2008) Possible Role of the Glycosaminoglycans in the Genesis of Atherosclerosis, in Ciba Foundation Symposium 12 - Atherogenesis: Initiating Factors (eds R. Porter and J. Knight), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470719954.ch8
- Published Online: 30 MAY 2008
- Published Print: 1 JAN 1973
Print ISBN: 9789021940137
Online ISBN: 9780470719954
It is assumed that the lipid deposits in atherosclerosis are formed by a filtration of plasma lipoproteins into the arterial wall. The glycosaminoglycans, which are a major constituent of the intercellular matrix, might aid in such a process by steric as well as ionic interactions with the lipoproteins.
The extracellular glycosaminoglycans are entangled, forming a chain network. When plasma is forced into this, filter effects known as molecular sieving might aid in the enrichment and retention of lipoproteins. Further, one of the glycosaminoglycans, dermatan sulphate, may bind very low-density and low-density lipoproteins by ionic interaction.