Chapter 14. The Role of Steroids in the Prevention of Corneal Graft Failure

  1. Ruth Porter and
  2. Julie Knight
  1. A. E. Maumenee

Published Online: 30 MAY 2008

DOI: 10.1002/9780470719985.ch14

Ciba Foundation Symposium 15 - Corneal Graft Failure

Ciba Foundation Symposium 15 - Corneal Graft Failure

How to Cite

Maumenee, A. E. (1973) The Role of Steroids in the Prevention of Corneal Graft Failure, in Ciba Foundation Symposium 15 - Corneal Graft Failure (eds R. Porter and J. Knight), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470719985.ch14

Author Information

  1. The Wilmer Institute, Johns Hopkins Hospital, Baltimore

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1973

ISBN Information

Print ISBN: 9789021940168

Online ISBN: 9780470719985

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Keywords:

  • immune response;
  • steroids;
  • corneal graft failure;
  • endothelial cells;
  • human corneal endothelium

Summary

Steroid therapy is of value in the prevention of the immune responses to corneal grafts in many instances. The effectiveness of this type of therapy depends on the severity of the immune response and on the stage at which the reaction is treated. In heavily vasculrtrized corneas where the immune response may begin within three or four weeks after operation, steroids are frequently incapable of preventing opacification of the graft. If the immune response occurs months or years after grafting and the reaction is noticed within a few days of its initiation, topical steroids may be extremely effective in clearing the inflammatory reaction.