Chapter 6. Immunologically Privileged Sites and Tissues

  1. Ruth Porter and
  2. Julie Knight
  1. C. F. Barker and
  2. R. E. Billingham

Published Online: 30 MAY 2008

DOI: 10.1002/9780470719985.ch6

Ciba Foundation Symposium 15 - Corneal Graft Failure

Ciba Foundation Symposium 15 - Corneal Graft Failure

How to Cite

Barker, C. F. and Billingham, R. E. (2008) Immunologically Privileged Sites and Tissues, in Ciba Foundation Symposium 15 - Corneal Graft Failure (eds R. Porter and J. Knight), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470719985.ch6

Author Information

  1. Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia; and Department of Cell Biology, The University of Texas Southwestern Medical School at Dullas

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1973

ISBN Information

Print ISBN: 9789021940168

Online ISBN: 9780470719985



  • malignant tissues;
  • cornea;
  • allografts;
  • decidual tissue;
  • skin pedicles


Allografts of both normal and malignant tissues have repeatedly been transplanted to anatomically unnatural sites for a variety of purposes. Orthotopic corneal grafts have long been used therapeutically with a high degree of success. Comparison of the fates of allografts transplanted to certain sites, including the anterior chamber of the eye, the cornea, the hamster's cheek pouch, the testis and the brain, with the fates of similar grafts transplanted elsewhere in the body has revealed that these sites are immunologically privileged since they can sustain graft survival for anomalously long periods.