Chapter 8. Corneal Graft Rejection: Clinico-Pathological Correlation

  1. Ruth Porter and
  2. Julie Knight
  1. Frank M. Polack

Published Online: 30 MAY 2008

DOI: 10.1002/9780470719985.ch8

Ciba Foundation Symposium 15 - Corneal Graft Failure

Ciba Foundation Symposium 15 - Corneal Graft Failure

How to Cite

Polack, F. M. (1973) Corneal Graft Rejection: Clinico-Pathological Correlation, in Ciba Foundation Symposium 15 - Corneal Graft Failure (eds R. Porter and J. Knight), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470719985.ch8

Author Information

  1. Department of Ophthalmology, University of Florida, Gainesville

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1973

ISBN Information

Print ISBN: 9789021940168

Online ISBN: 9780470719985



  • corneal graft rejection;
  • endothelium;
  • endothelial regeneration;
  • chronic keratitis;
  • graft failure


The outstanding clinical picture of the early graft reaction is given by the rejection of the endothelium, which is caused by lymphocytes. These cells reach the graft via the scar and unhealed Descemet's membrane or the uveal tissue. Typical clinical pictures can be observed and correlated with various stages of the rejection of experimental grafts.

Abnormal wound healing, vascularization of the cornea, adhesion of the iris to the scar and chronic inflammation facilitate rejection. Endothelial regeneration is possible in eyes with normal host endothelium but the prognosis is bad in eyes with dystrophic endothelium which cannot replace destroyed graft endothelium. Retrograft membranes or abnormal endothelial cells are frequent findings in the late stages of graft rejection.